After two years, 55% of those following the VLCD had an HbA1c that would be classified as non-diabetic, 67% of all diabetes medications used at baseline were no longer required, mean insulin dose was reduced by 81% (from 81.9 units/day to 15.5), and over 60% of those using insulin were able to omit it altogether (38). The gene discussed is INS; the disease is diabetes mellitus.