It is well-established that B-cell hyperactivity is a hallmark of the disease as evidenced by altered circulating levels of B-cells, increase in serum B-cell activating factor (BAFF); hypergammaglobulinemia; and pSS-associated autoantibodies against ribonucleoproteins SS-A/Ro and SS-B/La (2). The gene discussed is CALR; the disease is peeling skin syndrome.