BRD4 and Hepatic fibrosis: It has been reported that knockout of BRD4 through its specific small interfering RNA (siRNA) or inhibition using the BRD4 inhibitor JQ1 markedly reduces profibrotic mRNA expression, suppresses platelet derived growth factor (PDGF)-mediated proliferation of HSCs, and blocks the activation of HSCs in the carbon tetrachloride (CCl4)-induced mouse model of liver fibrosis (12–14).