Specifically, we examined the BRD4 expression pattern in human liver tissues from patients with liver fibrosis of various etiologies, elucidated the specific cell types of BRD4 expression in human liver fibrosis specimens, and then analyzed the correlation of the BRD4 expression level with the fibrotic degree and clinical features in liver fibrosis caused by chronic HBV infection. The gene discussed is BRD4; the disease is Hepatic fibrosis.