TNF and cancer: In another study, the risk of malignancy and mortality was higher in elderly patients treated with TP than in those with anti-TNF therapy (H= 3.017; 95% CI: 1.050–8.666; p = 0.0403 and HR= 3.682; 95% CI: 1.192–11.377; p = 0.0235, for malignancy and mortality, respectively) (67).