NUDT15 variants associated with low enzymatic activity do not change the total amount of TGNs but modify the ratio of TGTP and TGMP (49); therefore monitoring the levels of TGTP and TG integrated into the DNA could be useful to adjust the dose of TP in patients with NUDT15 deficiency (52). The gene discussed is NUDT15; the disease is hyperinsulinemic hypoglycemia, familial, 4.