Depending on the context, if chronic inflammatory rheumatism is suspected, the decision can be made to screen for antinuclear antibodies, a rheumatoid factor and anti-CCP antibodies for rheumatoid arthritis, anti-thyroid peroxidase antibodies for Hashimoto's disease, anti-neutrophil cytoplasmic antibodies to make sure vasculitis is not missed, and HLA B27 if spondyloarthritis is suspected. The gene discussed is TPO; the disease is vasculitis.