AKT1 and cancer: Studies in various cancers have shown that Angiotensin 1–7 induced inactivation of phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt), MAPK and VEGF signaling pathways (Machado et al., 2000; Benndorf et al., 2003; Gallagher and Tallant, 2004; Cook et al., 2010; Ni et al., 2012; Zhang et al., 2019).