ACE2 and COVID-19: The subsequent sections of this review, give an overview of SARS-CoV2, the presence of its receptor ACE2 (a component of RAS) in the oral tissues, the progressive and suppressive influence of RAS on cancer (tumorigenic and anti-tumorigenic), the progressive and suppressive influence of RAS on stress (anxiogenic and anxiolytic) and finally how do stress, cancer and COVID-19 interplay through RAS, when SARS-CoV2 hijacks the ACE2 receptor.