Complementing these findings, Yamamoto et al. (2018) reported that constitutive activation of autophagy (by whole-body expression of Beclin1F121A) preserved insulin signaling to AKT in WAT of HFD-fed mice by mitigating endoplasmic reticulum (ER) stress, a well described contributor to the development of insulin resistance. This evidence concerns the gene INS and Insulin resistance.