The translocation t(12;21) resulting in the formation of the chimeric transcription factor ETV6-RUNX1 that fuses ETV6 (HGNC:3495) and RUNX1 (HGNC:10471) genes is the most frequent structural aberration, accounting for 25% of B-cell precursor ALLs (B-ALL) (Mullighan, 2014; Pui et al., 2019). Here, ETV6 is linked to precursor B-cell acute lymphoblastic leukemia.