The lack of B-ALL in Sca1-ETV6-RUNX1 + Kdm5cf/wt + Mb1-Cre mice suggests that Kdm5c loss-of-function at the B-cell stage does not contribute to the malignant transformation of an ETV6-RUNX1+ preleukemic clone. Here, ETV6 is linked to precursor B-cell acute lymphoblastic leukemia.