To this end, Kdm5c loss, previously identified to be missense mutated in the murine ETV6-RUNX1+ B-ALL and in human relapse ETV6-RUNX1+ B-ALL (Rodriguez-Hernandez et al., 2017a), was introduced in the B-cell compartment of Sca1-ETV6-RUNX1 mice by crossing with a targeted Kdm5cf/wt mouse line obtained from a public repository (EMMA). The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.