Additionally, the onset of the disease in the Sca1-ETV6-RUNX1 + Kdm5cf/wt + Sca1-Cre mouse model (22%) should be earlier and more frequent than in the mouse that only has the first hit (Sca1-ETV6-RUNX1 mice) and, due to exposure to infections, acquires the second hit (10.75%) (Rodriguez-Hernandez et al., 2017a). The gene discussed is RUNX1; the disease is infection.