When we analyzed the mutational landscape of the generated ALLs by whole-exome sequencing of ETV6-ETV6–RUNX1 + Sca1-Cre T-ALL (n = 10) and ETV6-ETV6–RUNX1 + Sca1-Cre B-ALL (n = 2) (Figure 4), the mutations detected in T-ALL showed a significant overlap with human T-ALL (Liu et al., 2017), with Notch1 (HGNC:7881) and Bcl11b (HGNC:13222) mutations identified recurrently (Figure 4). Here, NOTCH1 is linked to acute lymphoblastic leukemia.