This first murine model of ETV6-RUNX1-associated B-ALL faithfully mimics the human disease and presents with similar secondary genetic hits, including recurrent disruption of Kdm5c (HGNC:11114), Pax5 (HGNC:8619), and Ebf1 HGNC:3126 (Rodriguez-Hernandez et al., 2017a). The gene discussed is KDM5C; the disease is precursor B-cell acute lymphoblastic leukemia.