Recently, GPIHBP1 auto-antibodies were shown to cause late-onset chylomicronemia by blocking the interaction between LPL and GPIHBP1 in 22 patients with a hitherto unexplained form of acquired hypertriglyceridemia (Beigneux et al., 2017; Miyashita et al., 2020). The gene discussed is LPL; the disease is hypertriglyceridemia.