LPL and atherosclerosis: For example, genetic variants of angiopoietin-like (ANGPTL) proteins 3 and 4 with a reduced capacity for LPL inhibition are associated with decreased risk of ASCVD (Dewey et al., 2016; Helgadottir et al., 2016; van Leeuwen et al., 2016; Stitziel et al., 2017; Klarin et al., 2018; Hahn et al., 2020; Wang Q. et al., 2020; Wang Z. et al., 2020).