Goulet et al. (2018) studied bladder exosomes that are internalized by normal fibroblasts. The authors observed activation of these fibroblasts revealed by enhanced proliferation and migratory capacity accompanied by a high α-SMA gene expression. In concordance, Zhou et al. (2018) observed that murine fibroblasts have 3T3 internalized PKH26 dye-labeled melanoma-derived exosomes. Here, ACTA1 is linked to melanoma.