In LUSC (p < 1e-12), ESCA (p = 1.864e-02), BRCA (p = 3.769e-12), LUAD (p = 1.248e-11), KIRP (p = 6.893e-09), PRAD (p = 1.624e-12), SARC (p < 1e-12), KIRC (p < 1e-12), LIHC (p < 1e-12), UCEC (p = 1.658e-12), TGCT (p < 1e-12), HNSC (p = 1.624e-12), BLCA (p = 1.934e-12), and PCPG (p < 1e-12), MUC4 was lowly methylated in tumor samples, while in READ (p = 2.688e-02) and COAD (p = 2.105e-03), MUC4 was highly methylated in tumor samples. The gene discussed is MUC4; the disease is neoplasm.