The results are consistent with the investigation of H. polygyrus infection-induced Tregs, in which adoptive transfer of Tregs from the cLP of H. polygyrus-infected mice as opposed to uninfected-mice significantly inhibited chronic colitis induced by CD4+CD25– T cells in Rag1 KO mice (Hang et al., 2013). This evidence concerns the gene CD4 and Chronic colitis.