In this study, we found that treatment with rTsPmy significantly increased the expression of TIGIT (Figure 7B) within CD4+Foxp3+ T cells and the proportion of CTLA4+Foxp3+ Treg cells in CD4+ T cells (Figure 7C) in mice with colitis compared with mice with colitis that received PBS only. The gene discussed is CTLA4; the disease is colitis.