RAG1 and Chronic colitis: The suppressive effect of rTsPmy-induced Tregs was also confirmed by passive transfer to Rag1 KO mice with chronic colitis induced by CD45RBhiCD4+CD25– naïve T cells; they had fewer clinical manifestations and pathological damage in colon that was associated with reduced levels of IL-17A and IFN-γ production in colonic LPMCs.