Compared with high-grade glioma, patients with low-grade glioma (LGG) have a significantly higher incidence of epilepsy (Huberfeld and Vecht, 2016), which may be related to the slower growth rate and higher IDH-1 mutation frequency of LGG (Cohen et al., 2013; Chen et al., 2018). Here, IDH1 is linked to central nervous system cancer.