FBXO42 and neoplasm: Considering that HIF-1α controls oxygen delivery into tumors via angiogenesis and metabolic adaptation of tumors to hypoxia via glycolysis (Semenza, 2002), the HIF-1α-JFK axis we identified in the present study may regulate processes (including glycolysis and fatty-acid β-oxidation) with broad impacts on tumor initiation and metastasis.