The HREs bound by HIF-1α and HIF-2α have both been shown to contain a conserved RCGTG core sequence, and there are reports that they share transcription target genes including IL-6, FILAG, and GLUT1, which are involved in the adaptation of tumor cells to hypoxia (Keith et al., 2011); thus, it is possible that HIF-2α may also bind to the HRE in the JFK promoter. The gene discussed is EPAS1; the disease is neoplasm.