Briefly, HIF-1α overexpression, but not FOXP3 nor E2F1, has been reported to be closely related to high histological grade, lymph node metastasis, large tumor size, and increased angiogenesis in breast cancer (Qin et al., 2006; Yamamoto et al., 2008; Li et al., 2018), which is consistent with the function of JFK. The gene discussed is FBXO42; the disease is breast cancer.