TET2 and cancer: To identify new gene(s) that is potentially involved in the regulation of DNA de/methylation process (Figure 1A), we performed a comprehensive analysis of mutations targeting three families of genes which are known to be involved in DNA de/methylation; two IDH genes (IDH1 and IDH2), three TET genes (TET1, TET2, and TET3) and four DNMT genes (DNMT3A, DNMT3B, DNMT3L, and DNMT1) in 34 cancer types.