PTPN11 and acute myeloid leukemia: Notably, we also identified additional new genes which are mutated in AML in a statistically significant, mutually exclusive manner with genes know to be involved in DNA de/methylation, such as gene pairs of CBFB/DNMT3A, KMT2A/DNMT3A, PTPN11/IDH2, and ATRX/IDH2 (Figures 1D,E), suggesting potential function of these genes in regulating DNA de/methylation process.