SCAF11 and fibrosis: Upon treatment with CCl4, Casp11–/– mice developed a similar level of advanced fibrosis compared to wild-type (wt) mice (collagen proportionate area measurement: 5.3 ± 0.3 vs. 5.8 ± 0.5%, p = 0.36; result not shown), but were significantly protected from hepatic and extra-hepatic organ injury following i.p. injection of LPS (4 mg/kg) (Figure 4A).