Downregulation of miR-29c-3p promoted NPC cell migration and invasion by targeting TIAM1 (Liu et al., 2013); miR-375-3p plays roles as a tumor suppressor by targeting oncogene PDK1, which promotes the proliferation, migration, and invasion of NPC cells (Jia-Yuan et al., 2020). The gene discussed is PDK1; the disease is nasopharyngeal carcinoma.