BCL2 and osteosarcoma: Qin et al. (2019) found circ_PVT1 was increased in NSCLC tissues and cells via targeting miR-497 and indirectly regulating Bcl2 expression. The increased expression of circ_PVT1 was found in osteosarcoma; circ_PVT1 would induce metastasis via targeting miR-526b/FOXC2 signal pathway (Qin et al., 2019). Chen et al. uncovered that the upregulated circ_PVT1 could promote tumor growth by sponging miR-125, which would be an underlying mechanism of gastric cancer (Chen et al., 2017).