Previous studies showed that infiltrated immune cells in TME, including TAMs, neutrophils, dendritic cells, and CD8 + T cells, were associated with the prognosis of CRC patients and response to ICB therapy (Tran Janco et al., 2015; Stanton and Disis, 2016; Fridman et al., 2017; Wu and Dai, 2017). The gene discussed is CD8A; the disease is colorectal carcinoma.