As YTH family mainly influenced the stability and translation of mRNA (Wang et al., 2014; Shi et al., 2017), we presumed that the half-life of PSMC5 was prolonged and the translation efficacy of PSMC5 might be enhanced, resulting in the upregulation of PSMC5 in CRC cells. The gene discussed is PSMC5; the disease is colorectal carcinoma.