For example, β-hydroxy butyrate (BHB), an effective inhibitor of the NLRP3 inflammasome in response to multiple activation stimuli including adenosine triphosphate (ATP), silica, and monosodium urate (MSU) crystals, almost completely blocks all aspects of inflammasome activation and pyroptosis induced by ATP and MSU crystals in PD (Youm et al., 2015; Deora et al., 2017). Here, NLRP3 is linked to Parkinson disease.