Zhang S. et al. (2012) have found that c-MYC downregulation contributed and induced teratocarcinoma cell differentiation caused by activation of Wnt/β-catenin signaling. Furthermore, another study has demonstrated that knockdown of c-MYC attenuated Wnt/β-catenin-mediated induction of human sertoli cell proliferation (Li et al., 2012). The gene discussed is MYC; the disease is teratocarcinoma.