In venous thrombosis, hypoxia and inflammatory stimuli induced the coagulation cascade under low shear stress via the activation and regional release of relevant transcriptional factors [hypoxia-inducible factor 1 (HIF-1) and early growth response 1 (EGR-1)] and TFs (Bovill and van der Vliet, 2011). Here, EGR1 is linked to Venous thrombosis.