Several TLRs have been described as important molecules in the resistance to T. cruzi experimental infection, such as TLR2 (Bafica et al., 2006), TLR4 (Oliveira et al., 2010), TLR7 (Caetano et al., 2011), and TLR9 (Bartholomeu et al., 2008). The gene discussed is TLR4; the disease is infection.