The univariate and multivariate analysis revealed that CTLA43 (p=0.00444), HAVCR2 (p=0.0019), age (p=0.0038), pTNM stage (p<0.0001), and tumor grade (p=0.00013) were independent factors affecting the prognosis of KIRC patients (Figures 4A, B). Here, HAVCR2 is linked to neoplasm.