Bioinformatics analysis showed that miR-193a-5p was low expressed in colon cancer, while YY1 and NF-кB -p65 were overexpressed, the results were validated using 10 pairs of clinical samples, and the latter two were moderately correlated in CRC (Pearson, R=0.39), in addition to these, enrichment analysis shows that lnc-TLCD2-1 is associated with positive regulation of NF-KappaB signaling. This evidence concerns the gene YY1 and malignant colon neoplasm.