In conclusion, lnc-TLCD2-1 can induce radiation resistance of CRC, and the possible mechanism is the regulation of YY1/NF-кB -p65 by targeting miR-193a-5p.Lnc-TLCD2-1 promote the proliferation of CRC, and patients with high expression of it have a shorter survival. The gene discussed is YY1; the disease is colorectal carcinoma.