To analyze the underlying mechanism of METTL3-mediated m6A modification in the regulation of TMZ resistance, we screened a series of TMZ-resistant genes (ANPG, CBX5, MGMT, MSH2, MSH6, MLH1, MPG, XRCC3, and XPC), revealing that METTL3 overexpression significantly increased the MGMT and ANPG expression in GBM cells (Figure 4A). This evidence concerns the gene MSH2 and glioblastoma.