MLH1 and glioblastoma: To analyze the underlying mechanism of METTL3-mediated m6A modification in the regulation of TMZ resistance, we screened a series of TMZ-resistant genes (ANPG, CBX5, MGMT, MSH2, MSH6, MLH1, MPG, XRCC3, and XPC), revealing that METTL3 overexpression significantly increased the MGMT and ANPG expression in GBM cells (Figure 4A).