We found that single nucleotide variation (SNV) or insertion/deletion (INDEL) mutations were frequently detected in EGFR, CSMD2, BRAF, TP53 and RYR2 genes in lung cancer samples (Figure 2 and Supplementary Table 6), while frequent copy number alterations were found in RYR2, RELN, DMBT1, CSMD2 and NOTCH1 (Supplementary Table 7). The gene discussed is NOTCH1; the disease is lung cancer.