To decode the emergent cell fates during initiation and progression of colorectal cancer (CRC) in the adult Drosophila midgut, two salient driver mutations (55) in adenomatous polyposis coli (Apc, in WNT pathway) (74) and Ras (in the EGFR pathway) (75) were incorporated into the ISC network. Here, EGFR is linked to colorectal carcinoma.