In this work, the authors show that MET is highly expressed at the plasma membrane of pancreatic cancer cells, and that TR1801-ADC, a novel antibody drug conjugate composed of a MET antibody conjugated to the highly potent pyrrolobenzodiazepine toxin-linker Tesirin was highly effective in MET-overexpressing patient derived xenografts, and synergized with Gemcitabine, even in tumors previously demonstrated to be resistant to Gemcitabine (183). This evidence concerns the gene MET and familial pancreatic carcinoma.