PIK3R1 and hepatocellular carcinoma: It is concluded that FOXA1 promotes cell proliferation and inhibits apoptosis (62), whereas FOXA1 is also found to suppress hepatocellular carcinoma cell viability and motility by transcriptional inactivation of phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) in PI3K/Akt signaling (63).