To patients with HCV infection to HCC, there are not only DNA methylation of targeted enhancers, enriched for the binding sites of the transcription factors, FOXA1, FOXA2, and HNF4A, and decreased histone H3 lysine 27 trimethylation (H3K27me3), caused by the EZH2 inhibitor GSK343, but also negatively associated with increased CG dinucleotide density and polycomb-mediated repression on genes involved in stem cell development (34). This evidence concerns the gene HNF4A and hepatocellular carcinoma.