For the roles of histone methylation on special HCV-induced HCC, it has been reported that overexpression of KDM5B/JARID1B, a member of JmjC histone demethylase, could enhance HCC cell proliferation through the regulation of its downstream genes, E2F1 and E2F2 (75). This evidence concerns the gene E2F1 and hepatocellular carcinoma.