While concurrent decrease or increase of NOTCH pathway elements and DCLK1 was also reported in crypt epithelial stem cells following radiation injury (65), epithelial tuft cells (66), and enteric infection (67), further supporting the role of DCLK1 in NOTCH signaling regulation, additional studies are warranted to decipher the mechanism underlying a cross-talk between DCLK1 and NOTCH activities in HNSCC. This evidence concerns the gene DCLK1 and head and neck squamous cell carcinoma.