Our analyses of a TMA containing HNSCC tumors obtained from 233 newly diagnosed and 40 recurrent patients revealed that high DCLK1 staining was strongly associated with decreased survival, confirming a previous report showing that DCLK1 mRNA level correlated with poor clinical outcome in a smaller cohort of NSCC patients that underwent surgery and postoperative radiotherapy (17). Here, DCLK1 is linked to head and neck squamous cell carcinoma.