Although this is merely the tip of the icebergs in assessing the application potential of NRP2 pathway blockade by N2E4, these findings suggested that N2E4 could restrain interaction between NRP2 with integrinβ1 to inhibit FAK/Erk/HIF-1a/VEGF signaling, limiting growth and metastasis of pancreatic cancer (Figure 7). Here, HIF1A is linked to pancreatic neoplasm.