While the combination of 5-FU+Cur exhibited a significant attenuation in tumor volume in animals bearing MDA-MB-231TS xenografts (Figures 5A-i, B), which were in complete concordance with the previous results (Figure 2B), the combination was unsuccessful in eliciting any significant effect on tumor volume in mice harboring MDA-MB-231TS- xenografts, compared to mice treated with 5-FU alone, emphasizing the role of TS as a critical factor in mediating the synergistic effect (Figures 5A-ii, C). The gene discussed is TYMS; the disease is neoplasm.