Finally, when we tried to explore the potential mechanisms, we found that the prognostic risk score had a close connection with stromal score, and patients in high-risk score group exhibited an increased abundance of Macrophages.M0 and decreased abundance of resting memory CD4 T cells in TCGA-LIHC dataset, which suggested that the signature was significantly associated with HCC immune microenvironment. The gene discussed is CD4; the disease is hepatocellular carcinoma.