The results of subgroup analysis further showed that loss of IL-34 expression was related to poor prognosis for LUAD patients who were older than 65 (P = 0.006), male (P = 0.004), in stage III (P = 0.007), with tumor diameter T3 (P = 0.036), or M0 (No distant metastasis, P = 0.005). The gene discussed is IL34; the disease is neoplasm.