In the PPI network of CLCF1 (Supplementary Figure 6A), the signal transducer and activator of transcription 3 (STAT3) is upregulated in PTEN-mut but not in the PTEN-wt subgroup (PTEN-mut vs. Normal, PTEN-wt vs. Normal), showing STAT3 is correlated with PTEN-mut glioma. The gene discussed is PTEN; the disease is central nervous system cancer.