PTEN and glioblastoma: We then concentrate on glioblastoma only or lower grades only to analyze the effect of PTEN states in IDH-wt, including 65% IDH-wt/GBM/PTEN-wt, 35% IDH-wt/GBM/PTEN-mut, 81% IDH-wt/LGG/PTEN-wt, and 19% IDH-wt/LGG/PTEN-mut (Figure 5A).