In the PPI network of OS9 (Supplementary Figure 6C), OS9 and derlin 2 (DERL2) involve in protein processing in the endoplasmic reticulum and complicate CFTR (Cystic fibrosis transmembrane conductance regulator) causes cystic fibrosis pathways, which may be associated with the prognosis of glioma with mutant PTEN. Here, OS9 is linked to central nervous system cancer.