Notably, 5/14 OPR-DEGs, including TDH, SSTR5, HMGN5, LGR6, and SEL1L3, also have different expressions between high-risk patients and low-risk patients in the TCGA PTEN-wt subgroup (Figures 3H–L, p < 0.001), suggesting that they are associated with the prognosis of PTEN-wt glioma. This evidence concerns the gene HMGN5 and central nervous system cancer.