For example, miR-21 was found to be oncogenic in HNSCC (28); miR-100 expression is decreased in oral cancer (29); and CDK6 is highly expressed in HNSCC (30), while S100 calcium binding protein B (S100B) expression is downregulated during carcinogenesis (31). The gene discussed is S100B; the disease is head and neck squamous cell carcinoma.