Similarly, integrin beta 3 (ITGB3) was reportedto play a central role in the recognition of heparan sulfate proteoglycans(HSPGs)-associated EVs and subsequent focal adhesion kinase (FAK)-mediatedendocytosis of these vesicles [49].Furthermore, integrin composition and their consequent heterodimerization onsurfaces of cancer cell-derived exosomes was shown to affect theirtissue-specific targeting to the lungs and liver [50]. Here, ITGB3 is linked to cancer.