Treatment with chlorpromazine, which preventsthe generation of clathrin-coated pits at the cell membrane, inhibited EV uptakeby phagocytic cells and ovarian cancer cells respectively [52,53].Importantly, the siRNA-mediated depletion of the clathrin heavy chain (CHC)inhibited EV internalization [54],indicating that CME is at least in part involved in EV uptake. This evidence concerns the gene CLTC and ovarian cancer.