Nevertheless, the C9orf72 mutation has been found as the most common mutation with around 20~40% occurrence rate in familial ALS, followed by superoxide dismutase 1 (SOD1) mutation with 5~20% rate, TAR DNA-binding protein (TDP43) mutation with 5~10% rate, and gene encoding fused in sarcoma (FUS) mutations with 5% amongst various others [65–67]. Here, TARDBP is linked to amyotrophic lateral sclerosis.