Having this in mind, we designed a cross-sectional, observational study to investigate possible association of PCSK9 with inflammation markers, including high-sensitivity C-reactive protein (hs-CRP), IL-6, TNF-α, oxidative stress markers, 8-isoprostanes (8-epiPGF2a), and ox-LDL, and endothelial dysfunction markers such as (sICAM-1) and (sVCAM-1) in a nondialysis population of stable CKD patients. This evidence concerns the gene TNF and endothelial dysfunction.