Furthermore, a study in a mouse model of colon adenocarcinoma found that IL-17's antitumour activity was linked to its ability to induce tumour angiogenesis by inducing a wide variety of angiogenic factors from fibroblasts and tumour cells, including VEGF, PGE2, keratinocyte-derived chemokine, and nitric oxide. This evidence concerns the gene VEGFA and neoplasm.