Two families of chemokines—CC (CCL-2, 3, 5) and CXC (CXCL-1, 2, 5, 6, 8)—employ CCR-2 with monocytes and CXCR-2+ with neutrophils, at the tumour spot which distinguishes between TAMs and tumour-associated neutrophils (TANs), wielding either pro- or antitumour response [42, 93]. This evidence concerns the gene CCL2 and neoplasm.