CAFs and penetrating leukocytes, obligated to chemokine receptors, are directly involved in cancer cell proliferation triggering PI3K/AKT/NF-κB and MAPK/ERK pathways besides helping the survival of tumour cells by hijacking programmed cell death mechanism, striking coherence between apoptotic (pro- and anti-) molecules [52]. This evidence concerns the gene NFKB1 and neoplasm.