To the best of our knowledge, this is the first study aimed at elucidating whether XKS exerts protective effects on endothelial function and endothelium-reparative capacity in CAD patients with anxiety/depression, and the role of CXCR7/p38/cleaved casepase-3 signaling pathway in XKS-regulated reendothelialization capacity. Here, ACKR3 is linked to coronary artery disorder.