Second, we found that XKS induced the regulation of CXCR7/p38/cleaved caspase-3 signaling contributes to the improvement of EPC-mediated endothelial reendothelialization in CAD with anxiety/depression; however, whether XKS exerts its beneficial effect on neuronal cells or other cells via different mechanisms still remains unclear. Here, MAPK14 is linked to major depressive disorder.