As it was found that XKS improved endothelial diastolic function and EPC-mediated reendothelialization capacity in CAD patients with anxiety/depression in this study, we continued to demonstrate that XKS facilitates reendothelialization in vivo and augments EPC function in vitro via the regulation of CXCR7/p38 signaling which meanwhile could reduce cleaved caspase-3-regulated apoptosis of EPCs. Here, ACKR3 is linked to depressive disorder.