We identified 10 signature trophic receptors (GRIN2A, GRIA2, CHRM1, GABRG2, PGRMC1, EPHA4, MAGED1, TNFRSF1B, TNFRSF1A, and RXRA) suggestive of a robust association with AD. This evidence concerns the gene GRIN2A and Alzheimer disease.