Ten signature receptors (GRIN2A, GRIA2, CHRM1, GABRG2, PGRMC1, EPHA4, MAGED1, TNFRSF1B, TNFRSF1A, and RXRA) interacting with cell cycle genes were displayed in the global regulation network (Figure 3), thus to enrich the cross-talking pathways of signature receptors in AD. This evidence concerns the gene PGRMC1 and Alzheimer disease.