TNF and obesity due to melanocortin 4 receptor deficiency: This strategy allowed us to assess the induction of an inflammatory state and the ability of the organisms to generate a compensatory response, suggesting that one of the physiological mechanisms that are improved with LIERLT is the reduction of the inflammatory state, which is consistent with different reports, in which it has been observed that exercise decreases the expression of inflammatory markers related to obesity, such as NF-κB, IL-6, and TNF-α, C-reactive protein, and cyclooxygenase 2 (COX2), in obese and aged Sprague Dawley rats [66, 67].