The activating of mitochondrial biogenesis through the PGC-1α/SIRT1 pathway was determined in rabbit's proximal renal tubular cells when exposed to isoflavones (daidzein, genistein, and formononetin) [86], flavones (wogonin and baicalein) in L6 skeletal muscle cells [87], and flavan-3-ol, in skin fibroblasts from Down's syndrome patients [88]. Here, SIRT1 is linked to Down syndrome.