Swami et al. [261] demonstrated that in prostate cancer patients, genistein consumption provoked a decrease in COX-2 and an increase in p21 gene expression in prostate tissue obtained by prostatectomy, suggesting that genistein consumption could be beneficial in prostate cancer chemoprevention and/or treatment through the inhibition of the prostaglandin pathway. The gene discussed is PTGS2; the disease is prostate cancer.