Urban et al. [250] revealed an important issue: soy protein beverage (containing significant levels of genistein and daidzein) supplementation in men reduced serum cholesterol levels but not the prostate cancer biomarkers prostate-specific antigen (PSA) and p105erB-2 [250]; the same result was obtained by other authors years later [251, 252]. The gene discussed is KLK3; the disease is Familial prostate cancer.