TP53 and esophageal squamous cell carcinoma: In esophageal squamous cell cancer, TE-2 (p53, wild) and TE-1 (p53, mutant) cell lines in human genistein (30 μM) upregulate the radiosensitivity of cell lines by suppressing the p42/p44 extracellular signal of regulated kinase and radiation-stimulated activation of the survival signal and Akt/PKB [111, 112].