Flavonoid binding protein 4 (FBP4) inhibits the expression of MFN1 in human aortic endothelial cells, but enhances the expression of dynamin-related protein1 (Drp1) and mitochondrial fission protein 1 (Fis1), suggesting mitochondrial fusion and fission dynamics are impaired, which induces oxidative damage of blood vessels and promotes the development of atherosclerosis [36]. The gene discussed is FIS1; the disease is atherosclerosis.