In multivariable models adjusted for age, sex, obesity, vascular risk factors, therapies before admission, acute stroke treatment, stroke subtype, NIHSS at admission, infarct size, and serum levels of IL-6, Hs-CRP, and glucose, IL-10 levels in the highest quartile (>5.24 pg/mL) were associated with a reduced risk of a poor functional outcome (OR = 0.35; 95%CI = 0.19–0.63; P < 0.001). Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.