Most importantly, in addition to those shown to associate with AD in the past, we found several new SNP loci, including rs6311 (HTR2A), rs6313 (HTR2A), rs1354269 (NAV2), rs1946518 (IL18), rs1799986 (LRP1), rs690705 (RFC3), and rs7943454 (LUZP2), whose p values were highly significant(as shown in Table 4). The gene discussed is LRP1; the disease is Alzheimer disease.