Although Miat has been shown to be involved in RNA splicing in neuronal and renal cells 18, 53-55, such as by interaction with the Qki and Srsf1 splicing factors to alter the splicing of Disc1 and ErbB4 in schizophrenia 56, 57, our study for the first time shows that Miat profoundly contributes to the RNA splicing in hypertrophic hearts. The gene discussed is SRSF1; the disease is schizophrenia.